Data on Swiss grapevine growers' production, pest management and risk management decisions.

We present survey data from 436 grapevine growers across Switzerland and their production, pest, and risk management decisions. The online survey was conducted in spring 2022 in the three main official languages in Switzerland (German, French, Italian). The survey was used to obtain information on variety choice and farm management strategies, as well as farmer, farm, and spatial environmental characteristics. Moreover, we collected information around fungus-resistant grapevine varieties such as knowledge, attitudes, and perceptions of these varieties. We also elicited the current cultivation and growers' intentions on future acreage under these varieties. In addition, data were collected on growers' pest management strategies against weeds, insects, and fungi. Characteristics of the farm manager collected include education, farming goals, wine-related expertise, and information sources used. Information about the farm consist of marketing channels, labels, direct payment schemes, production systems and pesticide application machinery, among other details. Moreover, risk and time preferences, self-efficacy and locus of control were collected via self-assessed scales. The survey data were matched with spatial climatic data on municipality level (e.g. on temperature, precipitation, the number of yearly hail days, average sunshine duration and relative humidity) as well as pest pressure (e.g. infection risk by Oidium and Peronospora viticola) at weather station level.

Farm-level data on production systems, farmer- and farm characteristics of apple growers in Switzerland.

We here present survey data from apple growers across Switzerland. Data from 245 apple growers was collected, using an online survey in French and German in 2022. The sampled growers represent 24.4% from total land under apples. Apple production is one of the most economically relevant and pesticide intensive crops. Hence, the focus of the survey is on growers' pest management decisions and marketing strategies. Survey data contains details on growers' agronomic practices such as grown cultivars, pest management against fungi, insects, and weeds, as well as pesticide use for cosmetic purposes. Moreover, we collected information on pest management after harvest, i.e. storage loss strategies. Marketing characteristics include the sales channel chosen as well as labels used and contract arrangements with buyers. Moreover, detailed data about farm management strategies, behavioral factors, as well as other farm- and farmer characteristics was collected. Survey data is matched with a rich set of environmental data, i.e. precipitation, temperature, and apple scab infection risk.

Barriers to evidence use for sustainability: Insights from pesticide policy and practice.

Calls for supporting sustainability through more and better research rest on an incomplete understanding of scientific evidence use. We argue that a variety of barriers to a transformative impact of evidence arises from diverse actor motivations within different stages of evidence use. We abductively specify this variety in policy and practice arenas for three actor motivations (truth-seeking, sense-making, and utility-maximizing) and five stages (evidence production, uptake, influence on decisions, effects on sustainability outcomes, and feedback from outcome evaluations). Our interdisciplinary synthesis focuses on the sustainability challenge of reducing environmental and human health risks of agricultural pesticides. It identifies barriers resulting from (1) truth-seekers' desire to reduce uncertainty that is complicated by evidence gaps, (2) sense-makers' evidence needs that differ from the type of evidence available, and (3) utility-maximizers' interests that guide strategic evidence use. We outline context-specific research-policy-practice measures to increase evidence use for sustainable transformation in pesticides and beyond.

Supporting young people's transition from children's to adult services in the community.

The Queen's Nursing Institute (QNI) is leading a project to improve young people's experience of transitioning from children's services to adult community health services. To gain an understanding of the current evidence, the QNI conducted a review of relevant UK literature from the last 10 years, focusing on community and primary care nursing. Despite the lack of evidence relating to effective practice in community and primary care settings, the literature search suggested that nurses could play a significant role in coordinating the transition process and working with the young person to prepare them for adult services. The review highlights that further work is required to translate current policy recommendations into practice, and the QNI will be supporting health and care professionals to improve transition by developing learning resources for district nurses, general practice nurses and educators, and promoting the sharing and application of best practice.

Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.

Metformin improves cardiovascular outcomes in type 2 diabetes, but its exact mechanisms of action remain controversial. We used hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy to determine the effects of metformin treatment on heart and liver pyruvate metabolism in rats in vivo. Both oral treatment for 4 weeks and a single intravenous metformin infusion significantly increased the cardiac [1-13C]lactate:[1-13C]pyruvate ratio but had no effect on the [1-13C]bicarbonate + 13CO2:[1-13C]pyruvate ratio, an index of pyruvate dehydrogenase flux. These changes were paralleled by a significant increase in the heart and liver cytosolic redox state, estimated from the [lactate]:[pyruvate] ratio but not the whole-cell [NAD+]/[NADH] ratio. Hyperpolarized MRI localized the increase in cardiac lactate to the left ventricular myocardium, implying a direct myocardial effect, though metformin had no effect on systolic or diastolic cardiac function. These findings demonstrate the ability of hyperpolarized pyruvate magnetic resonance spectroscopy to detect metformin-induced changes in cytosolic redox biology, suggest that metformin has a previously unrecognized effect on cardiac redox state, and help to refine the design of impending hyperpolarized magnetic resonance studies in humans.